Bipolar disorder is a form of mental illness that causes extreme mood changes from low to high and high to low. Highs happen when there is a period of mania where a person feels super energetic and have racing thoughts while low periods are accompanied by signs and symptoms of depression like feeling extreme anxiety and sadness. A person with bipolar disorder has mixed feelings and have a hard time focusing. Their emotions get too mixed up at times, and their mood could change in an instant.
The symptoms of Bipolar Disorder tend to appear during a person’s late teens or early adult years, but they can happen with children. The signs and symptoms of Bipolar disorder vary from one person to another making it difficult to diagnose.
Famous people who suffer from Bipolar disorder include Demi Lovato, Mariah Carey, Jean-Claude Van Damme, Catherine Zeta-Jones and artist Van Gogh.
Many high profile people and icons were believed to be suffering from a form of mental illness. World-renowned post-impressionist Van Gogh is one of them. Van Gogh was known for being eccentric and suffering from a tragic end through suicide at one point he even cut off part of his ear due to depression. He fluctuated from having extreme mania and depression and took his life through a self-inflicted gunshot wound at age 37.
8 Signs of Bipolar Disorder
- A decreased need for sleep
- Talking extremely fast, with racing thoughts
- Feeling too happy or in a high mode for a long period of time
- Feeling impulsive or restless
- Becoming easily distracted
- Feeling overconfident with abilities at times feeling like they have superpowers
- Engaging in risky behaviors like impulsive sex with strangers, gambling life savings and having mindless spending sprees.
- Feeling sad for a long period of time and withdrawing from family and suicidal thoughts when depression strikes.
Doctors and medical researchers are still baffled at Bipolar Condition, as they struggle to explain the dramatic changes in a person’s mood. But some researchers at the University of Michigan Medical School created a first stem cell model for bipolar disorder in an attempt to understand and find new treatments. The research they took was published in the journal of Translational Psychiatry. During the test, they took skin samples from people who were identified as having Bipolar disorder and people who do not have bipolar disorder for comparison.
The skin cells were exposed to controlled conditions and turned into induced pluripotent stem cells. These forms of stem cells have the ability to turn into other types of cells, afterward, they turned the induced pluripotent cells into neurons. They were able to measure and see differences in gene expression and realized that there are huge differences between stem cells derived from bipolar patients and those that were taken from people who do not have the condition. The neurons they took from Bipolar patients showed more genes for membrane receptors and ion channels than the neurons taken from non-bipolar patients in connection with receptors and channels used in sending and receiving calcium signals between the cells.
Calcium plays a crucial role in neuron development, and the differences in the early brain development of a person could be the reason why a person suffers from mental disorders like bipolar.
For example, when there are lithium changes it can affect calcium signals that are sent and received. These new cell lines are the ones who determine the mechanism behind specific cells of bipolar patients. Researchers found that some bipolar patients had issues during their brain development, their neurons suffer from signaling and misdirection and this could greatly impact them later on in life. This means that the differences they found out could mean that bipolar disorder could be caused by a combination of genetic vulnerabilities.
At present, the current medications being used are antidepressants, mood stabilizers, and antipsychotics. But unfortunately, some of these drugs have side effects that leave people with Bipolar disorder more uncontrolled symptoms.
Stem Cell Therapy as Personalised Treatment for Bipolar Disorder
In a study by author Melvin McInnis of the Department of Psychiatry at the University of Michigan Medical School, they believe that the stem cell model could lead to customized treatments for bipolar disorder.
Stem cell therapy is believed to be the key to understanding the origins of bipolar disorder and how to treat it. If we know the origin or how the disease started we can start testing drugs that are far more effective than what we are using now. Researchers are currently processing stem cell lines from bipolar patients with the goal of sharing their cell lines with other investigators so that the future can be brighter for people with bipolar. Medical researchers want to find out why does the brain works for some people and why do some people have limited abilities even deficiencies and abnormalities.
Various researchers are now doing direct experiments with brain cells from mentally ill humans with the hopes of getting precise treatment. Lab-grown neurons and related cells are carefully observed to get into the bottom of bipolar cases.
There is a San Diego research team that believes that some of the genetic errors that humans suffer from could be because of faulty protein regulation and the activity of glial cells that affect neuron function. When these genetic errors come together they can lead to bipolar symptoms and even schizophrenia.
As a result, a new wave of research is ongoingly fueled by Shinya Yamanaka’s Nobel-winning experiments on cellular reprogramming from almost a decade ago. His findings of creating induced pluripotent stem cells are now being applied to studying mental illness. These movements were largely inspired by the ability to make patient-specific stem cells- once we are able to that, then all sorts of disease could already be investigated.
Creating Mini-Brains inside the Lab
Scientists have a hard time studying mental illness due to the fact that the brain remains very inaccessible while a patient is still alive. They first had to find a way around that by linking certain genetic mutations to disorders. But there are still many mysteries regarding mental illnesses like autism, bipolar disorder, and schizophrenia.
But the study of stem cells and therapies it is able to provide is breathing hope and life to scientists who want to find the cure. They are now developing iPSCs of 3-D brain organoid models or mini-brains composed of neural stells to better understand the features of the human brain. The goal is to arrive at personalized solutions or customized cure for brain disorders with the help of stem cell therapy. Scientists are predicting that they are going to be able to reach a breakthrough within a decade.
What Can Stem Cell Therapies Currently Help Humans With?
Stem cells have the unique ability to regenerate and offer powerful anti-aging effects. It is highly regarded and deemed valuable by the medical community because it is now proven effective to strengthen organs, tissues, and cells that were damaged by stress, injury or exposure to toxins and pollutants.
Stem Cell Anti-Aging Therapy
FGAAA is offering an advanced form of anti-aging treatment that provides rejuvenation for the body. Patients who receive rejuvenation therapy from the clinic receive numerous benefits including:
- Reduced fatigue and tiredness
- Reduced aged spots, fewer lines, and wrinkles
- Youthful appearance and better skin tone
- Boost in energy, stamina, and vitality
- Relief from back pain, aches, and pains including stiffness of joints
- Boost in sexual prowess and libido
- Easier weight maintenance
- Feelings of happiness and mental clarity
- Better and healthier outlook in life
- Agility and better stamina that aids exercise activities
Anti-aging effects are one of the many benefits of stem cell therapy. A person injected with fresh stem cells, experience better blood flow, it also helps the skin rejuvenate from within leading to increased collagen and younger-looking skin.
Living Proof of the Power of Stem Cells
Most people at age 72 retire and become grumpy, have less interest do to their hobbies and hardly have the energy to follow their dreams due to recurring muscle and bodily pains. Too many people, aging is a dread, something to be scared about, due to the many limitations it creates. But not for Lourdes Duque Baron.
Because of the powerful anti-aging treatment that is coursing through her veins, she is able to stand out. Stem cell therapy allows Lou Baron to remain active, and full of life. She is able to focus and complete various projects including award-winning film Tombstone Pillow. Not only that she is also an International Author of two best-selling books ” Scripted in Heaven” and ” I Called Myself Cassandra”.
A fresh batch of stem cells is injected through her veins and this is what regenerates her entire system. Stem cell-based therapies that she is receiving from the world-class clinic Feeling Good At Any Age The One-Stop Rejuvenation Center in California allow her to live as a superhuman being.
Only recently she has landed the cover of Hollywood Monthly. She was inspired by her personal experience on stem cell therapy and created the book New Breed of Homo Sapiens.
Her book deviates from scientific discourse and was written in a clear, easy to understand language so that the message and power of stem cells would be understood by everyone.
Lou Baron’s third book New Breed of Homo Sapiens is a textbook made easy and written in Friendly Language for people who want to get the best out of Stem Cell-Based Therapies.
Listen to Her Amazing voice at age 72! All because of Stem Cell Therapy!